The stage runs perfectly flat across the Po Plain for 150 km, on straight roads (at times wide, at times narrower). As it takes its first pass through Monselice, the route draws a long, challenging “semi-circuit” of nearly 40 km, with two consecutive harsh climbs. Past Galzignano Terme, the route tackles the Roccolo, taking in 3 different climbs in a row (the Muro di Vallorto, max. 20%, the Castelnuovo climb and the “actual” Roccolo, max. 17%). The roads are relatively narrow, yet well-surfaced. The route drops into Cinto Euganeo and then tackles the Muro di Calaone (max. slope: 18%), coming from Rivadolmo, before heading for a fast stage finale.
Over the last 15 km, the route descends rapidly along a large road with wide hairpins, from Calaone towards Este. Past Este, the route straightens and levels out, all the way to Monselice. With approx. 3 km to go, the stage enters the urban area coming from the railway underpass, with one last sharp left-hand corner 400 m before the finish, leading into the home straight, on 8 m wide tarmac.