This ITT is played out entirely on city roads. Starting in Monreale, the route goes up, heading for the cathedral (running in an underpass/tunnel for 20 m), then takes a fast-running descent into the centre of Palermo. At the end of the descent, the route takes a left-hand turn (intermediate time recording); the second part of the stage features long straight stretches connected by wide bends. The route rises for 1 km and descends for three, so the profile is basically level, with some false-flat drags (sometimes going up, sometimes going down). The last 2,700 m run straight along Via della Libertà, all the way to the finish.
The final kilometres run flat all the way to the finish line, which sits on 7 m wide tarmac.