The start of the ITT is set in the centre of Cernusco sul Naviglio. The route takes the former Strada Statale Padana Superiore, then proceeds along wide, straight and well-paved avenues heading for Milan. At the beginning of Via Palmanova, the route encounters the underpass of the Tangenziale Est, followed by an overpass. After leaving Via Palmanova, the route merges onto Via Padova, where split time is taken. From here on, the course runs almost straight up to 2 km from the finish in Piazza Duomo.
In the stage finale, the route first runs on wide avenues, and then on narrowed roads over the last few hundred metres, with several consecutive 90-degree turns over the last 100 – 150 metres, before entering Piazza Duomo. The home straight (250 m) is on 6 m wide stone-paved road.