The start of the ITT is set in the centre of Senago. The stage is played out on wide and mostly straight roads, as far as Sesto San Giovanni. From here on, the course runs almost straight up to 2 km from the finish in Piazza Duomo. Tramway tracks, roundabouts and street furniture are found repeatedly along the route.
In the stage finale, the route first runs on wide avenues, and then on narrowed roads over the last few hundred metres, with several consecutive 90-degree turns over the last 100-150 metres, before entering Piazza Duomo. The home straight (250 m) is on 6 m wide stone-paved road.