The stage tackles a challenging climb early on, followed by 150 km of downhill and flat terrain. After cresting the Simplon Pass, the route features a technical descent leading back to Italy, with several tunnels. The roads are wide and straight in the first part, from the border to Lake Maggiore, and more intricate along the lakeshore. The route is somewhat rougher in the final part, past Sesto Calende, but still on well‑paved roads. Common traffic calming devices will be found in urban areas.
The stage finale is played out mostly in urban areas, with no particular impediments. The roads are straight, with hardly any curves. The pitch over the final kilometre hovers just below the 3% mark. The home straight (300 m) is on 8 m wide tarmac.