The stage is very long. The first 190 km take place on straight and broad fast roads, with a few tunnels along the way, but with no major climbs. The route then changes dramatically: the roads are narrower, and worn out at points. The Coppa Casarinelle climb (30 km before the finish) ascends in hairpins with 5-6% gradients to the Gargano, until 15 km from the finish.
The roads are undulating and twisting. The route runs uphill until 6 km from the finish, then downhill until -3 km, then further uphill to cross the town and head into the last short descent, from -2 km to the red flag. The home straight (1,200 m) is on 7.5 m wide tarmac, with a 2-3% incline.