A full mountain stage across the Apennines. The route rises early on, after the start in Isernia and heading towards Rionero Sannitico. After brushing by the iconic Macerone pass, the stage course takes in the first major climb in Roccaraso. The gradients then ease off, and the route continues mostly downhill all the way to the outskirts of Guardiagrele, before taking in the double ascent to the Blockhaus. The route climbs from Pretoro to Passo Lanciano, and then descends into Lettomanoppello. After circling the foot of the Majella, it rises towards the finish, passing through Roccamorice (as in 2017), and swirling through a series of hairpins with double‑digit gradients.