The start of the ITT is set on the home straight of the Autodromo Nazionale Monza (already stage twon in 1949 and 1985). After completing one lap of the circuit, the stage course takes the pit lane and passes behind the paddocks to enter the Monza Park. The route then emerges from Villa Reale (first time split), then proceeds along wide, straight and well-paved avenues. In Sesto San Giovanni, the route takes the railway underpass. The second time split is taken upon entering Viale Italia. From here on, the course runs almost straight up to 2 km from the finish in Piazza Duomo. As far as Milan is concerned, it counts 8 stages with start and finish, 47 starts and 77 arrivals (last arrival in 2015).
In the stage finale, the route first runs on wide avenues, and then on narrowed roads over the last few hundred metres, with several consecutive 90-degree turns over the last 100 - 150 metres, before entering Piazza Duomo. The home straight (150 m) is on 6-m wide stone-paved road.