The stage profile is wavy and twisting as it passes through several urban areas. The route starts downhill to the Val di Non, and takes an unprecedented climb to Passo della Mendola from the Fondo side (with steeper gradients). The course drops down into Bolzano and then climbs up the Eisack Valley, all the way to Bressanone. The riders will take in a succession of climbs and descents, with categorised summits in Elvas and Terento, leading to the foot of the final climb in Anterselva/Antholz.
The final climb is very demanding, as the road slopes at an average 8.5% gradient from 5.5 km to the finish until the red flag. After a short ascent, the route reaches the cross-country skiing track at the Biathlon stadium, then drops for 100 metres through the tunnel that passes under the road, to finally enter the stadium. The home straight (110 m) is on 6.5 m wide tarmac, after the shooting range.